Posters and Publications

Targeted Delivery Platform Publications

AACR Poster Presentation – UW – October 2017
The Phospholipid Ether Analog CLR 127 Delays Radiation-induced dsDNA Damage Repair in Pediatric and Adult Solid Tumors

Alkylphosphocholine Analogs for Broad Spectrum Cancer Imaging and Therapy
Tumor-specific alkylphosphocholine analogs were evaluated as imaging and therapy agents in patients and in animal models of human cancer.

American Society of Clinical Oncology (ASCO) 2014 Annual Meeting Oral Presentation – Pickhardt – UW – June 2014
A novel “diapeutic” molecular imaging agent for combined oncologic diagnosis and therapy in a broad spectrum of human cancers: Preliminary clinical experience with CLR1404

EMIT: Targeted Radiotherapy Oral Presentation – Pazoles – Novelos – January 2013
Cancer-Targeted Diapeutics: Radioiodinated Phospholipid Ether Analogs for Broad-Spectrum Imaging and Therapy

Imaging In 2020 Oral Presentation – Weichert – UW – October 2012
Molecular Diapeutics: Phospholipid Ether Analogs as Broad-Spectrum Cancer and Cancer Stem Cell Detection and Treatment

WMIC Poster Presentation – Weichert – UW – September 2012
First in Human Use of I-124-CLR1404, PET/CT in Primary and Metastatic Brain Tumors

WMIC Poster Presentation – Liu – UW – September 2012
Relative Biodistribution and Tumor Uptake of I-131-CLR1404, in Human Subjects with Advanced Colon Cancer

WMIC Poster Presentation – Traynor – UW – September 2012
Relative Biodistribution and Tumor Uptake of I-124–CLR1404, in Humans with Non–Small Cell Lung Cancer

AACR Poster Presentation – Weichert – UW – April 2012
I-124-CLR1404 and I-131-CLR1404: Broad spectrum diapeutic agents for cancer cell-targeted PET imaging and molecular radiotherapy

AACR Poster Presentation – Weichert – UW – April 2012
I-131-CLR1404 and CLR1404: Broad spectrum, cancer-targeted molecular radio- and chemotherapeutic phospholipid ether analogs

AACR Poster Presentation – Kuo – UW – April 2012
The novel phospholipid ether analog CLR1404 decreases glioblastoma stem cell proliferation, suppresses GBM growth, and improves survival

WMIC Poster Presentation – Weichert – UW – September 2009
Fluorescent Alkyl Phospholipid Analogs for Fluorescence Imaging of Tumors in vitro and in vivo

Journal of Medicinal Chemistry V49, pp. 2155-2165 – April, 2006 – Peer Reviewed Publication
Synthesis and Structure-Activity Relationship Effects on the Tumor Avidity of Radioiodinated Phospholipid Ether Analogues

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CLR 131 Publications

American Society of Clinical Oncology (ASCO) 2014 Annual Meeting Oral Presentation – Pickhardt – UW – June 2014
A novel “diapeutic” molecular imaging agent for combined oncologic diagnosis and therapy in a broad spectrum of human cancers: Preliminary clinical experience with CLR1404

American Society of Clinical Oncology (ASCO) 2014 Annual Meeting Poster – Lubner – UW – June 2014
A phase 1 study of phospholipid ether I-131-CLR1404 in patients with advanced solid tumors

EMIT: Targeted Radiotherapy Oral Presentation – Pazoles – Novelos – January 2013
Cancer-Targeted Diapeutics: Radioiodinated Phospholipid Ether Analogs for Broad-Spectrum Imaging and Therapy

Imaging In 2020 Oral Presentation – Weichert – UW – October 2012
Molecular Diapeutics: Phospholipid Ether Analogs as Broad-Spectrum Cancer and Cancer Stem Cell Detection and Treatment

WMIC Poster Presentation – Liu – UW – September 2012
Relative Biodistribution and Tumor Uptake of I-131-CLR1404, in Human Subjects with Advanced Colon Cancer

AACR Poster Presentation – Weichert – UW – April 2012
I-124-CLR1404 and I-131-CLR1404: Broad spectrum diapeutic agents for cancer cell-targeted PET imaging and molecular radiotherapy

AACR Poster Presentation – Weichert – UW – April 2012
I-131-CLR1404 and CLR1404: Broad spectrum, cancer-targeted molecular radio- and chemotherapeutic phospholipid ether analogs

Journal of Medicinal Chemistry V49, pp. 2155-2165 – April, 2006 – Peer Reviewed Publication
Synthesis and Structure-Activity Relationship Effects on the Tumor Avidity of Radioiodinated Phospholipid Ether Analogues

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CLR 124 Publications

American Society of Clinical Oncology (ASCO) 2014 Annual Meeting Oral Presentation – Pickhardt – UW – June 2014
A novel “diapeutic” molecular imaging agent for combined oncologic diagnosis and therapy in a broad spectrum of human cancers: Preliminary clinical experience with CLR1404

EMIT: Targeted Radiotherapy Oral Presentation – Pazoles – Novelos – January 2013
Cancer-Targeted Diapeutics: Radioiodinated Phospholipid Ether Analogs for Broad-Spectrum Imaging and Therapy

Imaging In 2020 Oral Presentation – Weichert – UW – October 2012
Molecular Diapeutics: Phospholipid Ether Analogs as Broad-Spectrum Cancer and Cancer Stem Cell Detection and Treatment

WMIC Poster Presentation – Weichert – UW – September 2012
First in Human Use of I-124-CLR1404, PET/CT in Primary and Metastatic Brain Tumors

WMIC Poster Presentation – Liu – UW – September 2012
Relative Biodistribution and Tumor Uptake of I-131-CLR1404, in Human Subjects with Advanced Colon Cancer

AACR Poster Presentation – Weichert – UW – April 2012
I-124-CLR1404 and I-131-CLR1404: Broad spectrum diapeutic agents for cancer cell-targeted PET imaging and molecular radiotherapy

Journal of Medicinal Chemistry V49, pp. 2155-2165 – April, 2006 – Peer Reviewed Publication
Synthesis and Structure-Activity Relationship Effects on the Tumor Avidity of Radioiodinated Phospholipid Ether Analogues

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CLR 1502 Publications

Neurosurgery V76, Issue 2, pp. 115–124 -February 2015 – A Peer Reviewed Publication
Fluorescent Cancer-Selective Alkylphosphocholine Analogs for Intraoperative Glioma Detection

PLOS ONE V9, Issue 10 – October, 2014 – Peer Reviewed Publication
Phospholipid Ether Analogs for the Detection of Colorectal Tumors

EMIT: Targeted Radiotherapy Oral Presentation – Pazoles – Novelos – January 2013
Cancer-Targeted Diapeutics: Radioiodinated Phospholipid Ether Analogs for Broad-Spectrum Imaging and Therapy

Imaging In 2020 Oral Presentation – Weichert – UW – October 2012
Molecular Diapeutics: Phospholipid Ether Analogs as Broad-Spectrum Cancer and Cancer Stem Cell Detection and Treatment

WMIC Poster Presentation – Weichert – UW – September 2009
Fluorescent Alkyl Phospholipid Analogs for Fluorescence Imaging of Tumors in vitro and in vivo

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